Differential response in downstream processing of CHO cells grown under mild hypothermic conditions
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چکیده
منابع مشابه
Differential Response in Downstream Processing of CHO Cells Grown Under Mild Hypothermic Conditions
The manufacture of complex therapeutic proteins using mammalian cells is well established, with several strategies developed to improve productivity. The application of sustained mild hypothermic conditions during culture has been associated with increases in product titer and improved product quality. However, despite associated cell physiological effects, very few studies have investigated th...
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ژورنال
عنوان ژورنال: Biotechnology Progress
سال: 2013
ISSN: 8756-7938
DOI: 10.1002/btpr.1726